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A role for p53 in base excision repair
Wild-type p53 protein can markedly stimulate base excision repair (BER) in vitro, either reconstituted with purified components or in extracts of cells. In contrast, p53 with missense mutations either at hot-spots in the core domain or within the N-terminal transactivation domain is defective in thi...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC145418/ https://ncbi.nlm.nih.gov/pubmed/11179235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.4.914 |
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