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Residues in substrate proteins that interact with GroEL in the capture process are buried in the native state

We have used a bioinformatic approach to predict the natural substrate proteins for the Escherichia coli chaperonin GroEL based on two simple criteria. Natural substrate proteins should contain binding motifs similar in sequence to the mobile loop peptide of GroES that displaces the binding motif du...

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Autori principali: Stan, George, Brooks, Bernard R., Lorimer, George H., Thirumalai, D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450189/
https://ncbi.nlm.nih.gov/pubmed/16537402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600433103
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