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Residues in substrate proteins that interact with GroEL in the capture process are buried in the native state

We have used a bioinformatic approach to predict the natural substrate proteins for the Escherichia coli chaperonin GroEL based on two simple criteria. Natural substrate proteins should contain binding motifs similar in sequence to the mobile loop peptide of GroES that displaces the binding motif du...

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Détails bibliographiques
Auteurs principaux: Stan, George, Brooks, Bernard R., Lorimer, George H., Thirumalai, D.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450189/
https://ncbi.nlm.nih.gov/pubmed/16537402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600433103
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