Neuroprotection by pharmacologic blockade of the GAPDH death cascade

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) participates in a cell death cascade wherein a variety of stimuli activate nitric oxide (NO) synthases with NO nitrosylating GAPDH, conferring on it the ability to bind to Siah, an E3-ubiquitin-ligase, whose nuclear localization signal enables the GAP...

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Main Authors: Hara, Makoto R., Thomas, Bobby, Cascio, Matthew B., Bae, Byoung-Il, Hester, Lynda D., Dawson, Valina L., Dawson, Ted M., Sawa, Akira, Snyder, Solomon H.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450161/
https://ncbi.nlm.nih.gov/pubmed/16505364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511321103
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