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Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

Wnt and Notch signaling have long been established as strongly oncogenic in the mouse mammary gland. Aberrant expression of several Wnts and other components of this pathway in human breast carcinomas has been reported, but evidence for a causative role in the human disease has been missing. Here we...

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Bibliografiske detaljer
Main Authors: Ayyanan, Ayyakannu, Civenni, Gianluca, Ciarloni, Laura, Morel, Catherine, Mueller, Nathalie, Lefort, Karine, Mandinova, Anna, Raffoul, Wassim, Fiche, Maryse, Dotto, Gian Paolo, Brisken, Cathrin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450156/
https://ncbi.nlm.nih.gov/pubmed/16501043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600065103
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