p21(WAF1/Cip1) is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation

In keratinocytes, the cyclin/CDK inhibitor p21(WAF1/Cip1) is a direct transcriptional target of Notch1 activation; loss of either the p21 or Notch1 genes expands stem cell populations and facilitates tumor development. The Notch1 tumor-suppressor function was associated with down-regulation of Wnt s...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Devgan, Vikram, Mammucari, Cristina, Millar, Sarah E., Brisken, Cathrin, Dotto, G. Paolo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2005
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1151665/
https://ncbi.nlm.nih.gov/pubmed/15964998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.341405
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