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p21(WAF1/Cip1) is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
In keratinocytes, the cyclin/CDK inhibitor p21(WAF1/Cip1) is a direct transcriptional target of Notch1 activation; loss of either the p21 or Notch1 genes expands stem cell populations and facilitates tumor development. The Notch1 tumor-suppressor function was associated with down-regulation of Wnt s...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1151665/ https://ncbi.nlm.nih.gov/pubmed/15964998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.341405 |
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