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Electron trap for DNA-bound repair enzymes: A strategy for DNA-mediated signaling

Despite a low copy number within the cell, base excision repair (BER) enzymes readily detect DNA base lesions and mismatches. These enzymes also contain [Fe(4)S(4)] clusters, yet a redox role for these iron cofactors had been unclear. Here, we provide evidence that BER proteins may use DNA-mediated...

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Detalhes bibliográficos
Main Authors: Yavin, Eylon, Stemp, Eric D. A., O’Shea, Valerie L., David, Sheila S., Barton, Jacqueline K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450131/
https://ncbi.nlm.nih.gov/pubmed/16505354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600239103
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