Calcium-dependent regulation of the voltage-gated sodium channel hH1: Intrinsic and extrinsic sensors use a common molecular switch

The function of the human cardiac voltage-gated sodium channel Na(V)1.5 (hH1) is regulated in part by binding of calcium to an EF hand in the C-terminal cytoplasmic domain. hH1 is also regulated via an extrinsic calcium-sensing pathway mediated by calmodulin (CaM) via binding to an IQ motif immediat...

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Detalhes bibliográficos
Main Authors: Shah, Vikas N., Wingo, Tammy L., Weiss, Kevin L., Williams, Christina K., Balser, Jeffrey R., Chazin, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450128/
https://ncbi.nlm.nih.gov/pubmed/16505387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507397103
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