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Arrangement and Mobility of the Voltage Sensor Domain in Prokaryotic Voltage-gated Sodium Channels

Prokaryotic voltage-gated sodium channels (Na(V)s) form homotetramers with each subunit contributing six transmembrane α-helices (S1–S6). Helices S5 and S6 form the ion-conducting pore, and helices S1-S4 function as the voltage sensor with helix S4 thought to be the essential element for voltage-dep...

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Main Authors: Shimomura, Takushi, Irie, Katsumasa, Nagura, Hitoshi, Imai, Tomoya, Fujiyoshi, Yoshinori
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044997/
https://ncbi.nlm.nih.gov/pubmed/21177850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.186510
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