Differential expression of IFN-α and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients

Loss of CD4(+) T cells, the hallmark of HIV pathogenesis, was suggested to be partly due to apoptosis. We recently reported that IFN-α produced by HIV-1-activated plasmacytoid dendritic cells (pDCs) contributes to CD4(+) T cell apoptosis by the TNF-related apoptosis-inducing ligand (TRAIL)/death rec...

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Bibliographic Details
Main Authors: Herbeuval, Jean-Philippe, Nilsson, Jakob, Boasso, Adriano, Hardy, Andrew W., Kruhlak, Michael J., Anderson, Stephanie A., Dolan, Matthew J., Dy, Michel, Andersson, Jan, Shearer, Gene M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1444883/
https://ncbi.nlm.nih.gov/pubmed/16632604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600363103
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