CD4(+) T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon–dependent, TRAIL/DR5-mediated apoptosis

It has been proposed that direct and indirect mechanisms contribute to the unresolved issue of CD4(+) T-cell depletion that results from HIV-1 infection. We recently reported that plasma levels of tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) are elevated in HIV-1–infected pa...

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Detalhes bibliográficos
Main Authors: Herbeuval, Jean-Philippe, Grivel, Jean-Charles, Boasso, Adriano, Hardy, Andrew W., Chougnet, Claire, Dolan, Matthew J., Yagita, Hideo, Lifson, Jeffrey D., Shearer, Gene M.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895067/
https://ncbi.nlm.nih.gov/pubmed/16046522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1243
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