Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease

BACKGROUND: Accumulating evidence suggests that inflammation plays an important role in the progression of Parkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase (COX), specifically the inducible isoform, COX-2, is believed to be a critical enzyme in the...

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Sonraí Bibleagrafaíochta
Main Authors: Vijitruth, Rattanavijit, Liu, Mei, Choi, Dong-Young, Nguyen, Xuan V, Hunter, Randy L, Bing, Guoying
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2006
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440849/
https://ncbi.nlm.nih.gov/pubmed/16566823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-3-6
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