Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease

BACKGROUND: Accumulating evidence suggests that inflammation plays an important role in the progression of Parkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase (COX), specifically the inducible isoform, COX-2, is believed to be a critical enzyme in the...

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Detalhes bibliográficos
Main Authors: Vijitruth, Rattanavijit, Liu, Mei, Choi, Dong-Young, Nguyen, Xuan V, Hunter, Randy L, Bing, Guoying
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440849/
https://ncbi.nlm.nih.gov/pubmed/16566823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-3-6
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