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Glycine–alanine repeats impair proper substrate unfolding by the proteasome
Proteasome ATPases unravel folded proteins. Introducing a sequence containing only glycine and alanine residues (GAr) into substrates can impair their digestion. We previously proposed that a GAr interferes with the unfolding capacity of the proteasome, leading to partial degradation of products. He...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1440830/ https://ncbi.nlm.nih.gov/pubmed/16601692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601058 |
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