TGFβ/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability

Homeobox (Hox) gene mutations and their altered expressions are frequently linked to human leukemia. Here, we report that transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP) inhibits the bone marrow transformation capability of Hoxa9 and Nup98-Hoxa9, the chimeric fusion form of Hoxa...

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Bibliographic Details
Main Authors: Wang, Ning, Kim, Hyung-Gyoong, Cotta, Claudiu V, Wan, Mei, Tang, Yi, Klug, Christopher A, Cao, Xu
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440313/
https://ncbi.nlm.nih.gov/pubmed/16525506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601037
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