PRMT5 Prevents Cardiomyocyte Hypertrophy via Symmetric Dimethylating HoxA9 and Repressing HoxA9 Expression

The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy. In cardiomyocyte hypertrophy induced by β-adrenergic receptor agonist isoprenaline (ISO), PRMT5 expression was decreased while HoxA9 was upregu...

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Vydáno v:Front Pharmacol
Hlavní autoři: Cai, Sidong, Liu, Rong, Wang, Panxia, Li, Jingyan, Xie, Tingting, Wang, Minghui, Cao, Yanjun, Li, Zhuoming, Liu, Peiqing
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793800/
https://ncbi.nlm.nih.gov/pubmed/33424610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.600627
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