Sirtuin 1 represses PKC‐ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy

BACKGROUND AND PURPOSE: Activation of PKC‐ζ is closely linked to the pathogenesis of cardiac hypertrophy. PKC‐ζ can be activated by certain lipid metabolites such as phosphatidylinositol (3,4,5)‐trisphosphate and ceramide. However, its endogenous negative regulators are not well defined. Here, the r...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Li, Jingyan, Huang, Junying, Lu, Jing, Guo, Zhen, Li, Zhuoming, Gao, Hui, Wang, Panxia, Luo, Wenwei, Cai, Sidong, Hu, Yuehuai, Guo, Kaiteng, Wang, Luping, Li, Zhenzhen, Wang, Minghui, Zhang, Xiaolei, Liu, Peiqing
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329629/
https://ncbi.nlm.nih.gov/pubmed/30414383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14538
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