SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy

NFATc4, a member from the Nuclear Factor of Activated T cells (NFATs) transcription factor family, plays a pivotal role in the development of cardiac hypertrophy. NFATc4 is dephosphorylated by calcineurin and translocated from the cytoplasm to the nucleus to regulate the expression of hypertrophic g...

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Vydáno v:Front Pharmacol
Hlavní autoři: Li, Zhenzhen, Zhang, Xiaoying, Guo, Zhen, Zhong, Yao, Wang, Panxia, Li, Jingyan, Li, Zhuoming, Liu, Peiqing
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331469/
https://ncbi.nlm.nih.gov/pubmed/30670969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01519
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