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SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy
NFATc4, a member from the Nuclear Factor of Activated T cells (NFATs) transcription factor family, plays a pivotal role in the development of cardiac hypertrophy. NFATc4 is dephosphorylated by calcineurin and translocated from the cytoplasm to the nucleus to regulate the expression of hypertrophic g...
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| Udgivet i: | Front Pharmacol |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6331469/ https://ncbi.nlm.nih.gov/pubmed/30670969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01519 |
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