Enhanced Immunogenicity to Mycobacterium tuberculosis by Vaccination with an Alphavirus Plasmid Replicon Expressing Antigen 85A

The immunogenicity of a plasmid DNA vaccine incorporating Sindbis virus RNA replicase functions (pSINCP) and expressing antigen 85A (Ag85A) from Mycobacterium tuberculosis was compared with a conventional plasmid DNA vector encoding Ag85A. pSINCP-85A was highly immunogenic in mice and gave enhanced...

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Detalles Bibliográficos
Main Authors: Kirman, Joanna R., Turon, Tara, Su, Hua, Li, Amy, Kraus, Carl, Polo, John M., Belisle, John, Morris, Sheldon, Seder, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Microbial Immunity and Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC143413/
https://ncbi.nlm.nih.gov/pubmed/12496215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.1.575-579.2003
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