Structural Basis for the Proinflammatory Cytokine Activity of High Mobility Group Box 1

High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, has been implicated as a proinflammatory cytokine and late mediator of lethal endotoxemia. HMGB1 is released by activated macrophages. It amplifies and extends the inflammatory response by inducing cytokine release and mediating ac...

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Autores principales: Li, Jianhua, Kokkola, Riikka, Tabibzadeh, Siamak, Yang, Runkuan, Ochani, Mahendar, Qiang, Xiaoling, Harris, Helena E, Czura, Christopher J, Wang, Haichao, Ulloa, Luis, Wang, Hong, Warren, H Shaw, Moldawer, Lyle L, Fink, Mitchell P, Andersson, Ulf, Tracey, Kevin J, Yang, Huan
Formato: Artigo
Lenguaje:Inglês
Publicado: ScholarOne 2003
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430376/
https://ncbi.nlm.nih.gov/pubmed/12765338
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