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Pharmacodynamics of a New Cephalosporin, PPI-0903 (TAK-599), Active against Methicillin-Resistant Staphylococcus aureus in Murine Thigh and Lung Infection Models: Identification of an In Vivo Pharmacokinetic-Pharmacodynamic Target
PPI-0903 is a new cephalosporin with broad-spectrum activity, including beta-lactam-resistant Streptococcus pneumoniae and Staphylococcus aureus. We used the neutropenic murine thigh and lung infection models to examine the pharmacodynamic characteristics of PPI-0903. Serum drug levels following fou...
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Main Authors: | , |
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Format: | Artigo |
Sprog: | Inglês |
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American Society for Microbiology
2006
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1426945/ https://ncbi.nlm.nih.gov/pubmed/16569855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1376-1383.2006 |
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