Potent Antiscrapie Activities of Degenerate Phosphorothioate Oligonucleotides

Although transmissible spongiform encephalopathies (TSEs) are incurable, a key therapeutic approach is prevention of conversion of the normal, protease-sensitive form of prion protein (PrP-sen) to the disease-specific protease-resistant form of prion protein (PrP-res). Here degenerate phosphorothioa...

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Detalhes bibliográficos
Main Authors: Kocisko, David A., Vaillant, Andrew, Lee, Kil Sun, Arnold, Kevin M., Bertholet, Nadine, Race, Richard E., Olsen, Emily A., Juteau, Jean-Marc, Caughey, Byron
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426446/
https://ncbi.nlm.nih.gov/pubmed/16495266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.3.1034-1044.2006
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