Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

Parp-1 and Parp-2 are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). Their involvement in double-strand break (DSB) repair mediated by homologous recombination (HR) or nonhomologous end joining (NHEJ) remains unclear. We addressed this question usin...

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Hauptverfasser: Hochegger, Helfrid, Dejsuphong, Donniphat, Fukushima, Toru, Morrison, Ciaran, Sonoda, Eiichiro, Schreiber, Valérie, Zhao, Guang Yu, Saberi, Alihossein, Masutani, Mitsuko, Adachi, Noritaka, Koyama, Hideki, de Murcia, Gilbert, Takeda, Shunichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1422167/
https://ncbi.nlm.nih.gov/pubmed/16498404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601015
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