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Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
The MDM2 homolog MDMX is an important regulator of p53 during mouse embryonic development. DNA damage promotes MDMX phosphorylation, nuclear translocation, and degradation by MDM2. Here we show that MDMX copurifies with 14-3-3, and DNA damage stimulates MDMX binding to 14-3-3. Chk2-mediated phosphor...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1422166/ https://ncbi.nlm.nih.gov/pubmed/16511560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601032 |
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