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α(1)-Adrenergic receptors prevent a maladaptive cardiac response to pressure overload

An α(1)-adrenergic receptor (α(1)-AR) antagonist increased heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), but it is unknown whether this adverse result was due to α(1)-AR inhibition or a nonspecific drug effect. We studied cardiac pressure...

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Bibliografiska uppgifter
Huvudupphovsmän: O’Connell, Timothy D., Swigart, Philip M., Rodrigo, M.C., Ishizaka, Shinji, Joho, Shuji, Turnbull, Lynne, Tecott, Laurence H., Baker, Anthony J., Foster, Elyse, Grossman, William, Simpson, Paul C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2006
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1421341/
https://ncbi.nlm.nih.gov/pubmed/16585965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI22811
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