Immunization of Aged Mice with a Pneumococcal Conjugate Vaccine Combined with an Unmethylated CpG-Containing Oligodeoxynucleotide Restores Defective Immunoglobulin G Antipolysaccharide Responses and Specific CD4(+)-T-Cell Priming to Young Adult Levels

Polysaccharide (PS)-protein conjugate vaccines, in contrast to purified PS vaccines, recruit CD4(+)-T-cell help and restore defective PS-specific humoral immunity in the immature host. Surprisingly, in the immunocompromised, aged host, anti-PS responses to conjugate vaccines are typically no better...

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Detalhes bibliográficos
Main Authors: Sen, Goutam, Chen, Quanyi, Snapper, Clifford M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1418916/
https://ncbi.nlm.nih.gov/pubmed/16552048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.4.2177-2186.2006
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