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Laser-Driven Microsecond Temperature Cycles Analyzed by Fluorescence Polarization Microscopy

We demonstrate a novel technique to achieve fast thermal cycles of a small sample (a few femtoliters). Modulating a continuous near-infrared laser focused on a metal film, we can drive the local temperature from 130 to 300 K and back, within a few microseconds. By fluorescence microscopy of dyes in...

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Detalhes bibliográficos
Main Authors: Zondervan, Rob, Kulzer, Florian, van der Meer, Harmen, Disselhorst, Jos A. J. M., Orrit, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1414575/
https://ncbi.nlm.nih.gov/pubmed/16443653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.075168
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