Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling

Individuals with Down syndrome (DS) are predisposed to develop acute megakaryoblastic leukemia (AMKL), characterized by expression of truncated GATA1 transcription factor protein (GATA1s) due to somatic mutation. The treatment outcome for DS-AMKL is more favorable than for AMKL in non-DS patients. T...

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Autori principali: Bourquin, Jean-Pierre, Subramanian, Aravind, Langebrake, Claudia, Reinhardt, Dirk, Bernard, Olivier, Ballerini, Paola, Baruchel, André, Cavé, Hélène, Dastugue, Nicole, Hasle, Henrik, Kaspers, Gertjan L., Lessard, Michel, Michaux, Lucienne, Vyas, Paresh, van Wering, Elisabeth, Zwaan, Christian M., Golub, Todd R., Orkin, Stuart H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413912/
https://ncbi.nlm.nih.gov/pubmed/16492768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511150103
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