Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds

Screening of a phage library for peptides that bind to clotted plasma in the presence of liquid plasma yielded two cyclic decapeptides, CGLIIQKNEC (CLT1) and CNAGESSKNC (CLT2). When injected intravenously into mice bearing various types of tumors, fluorescein-conjugated CLT peptides accumulated in a...

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Main Authors: Pilch, Jan, Brown, Darren M., Komatsu, Masanobu, Järvinen, Tero A. H., Yang, Meng, Peters, David, Hoffman, Robert M., Ruoslahti, Erkki
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413849/
https://ncbi.nlm.nih.gov/pubmed/16476999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511219103
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