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Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion

The attachment of circulating tumor cells to the blood vessels of distant organs is an important step in metastasis. We show here that experimental lung metastasis by two cell lines, B16F1 melanoma and 3LL lung carcinoma, is greatly reduced in transgenic mice that lack plasma fibronectin. This multi...

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Hlavní autoři: Malik, Gunjan, Knowles, Lynn M., Dhir, Rajiv, Xu, Shuping, Yang, Shuting, Ruoslahti, Erkki, Pilch, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880218/
https://ncbi.nlm.nih.gov/pubmed/20501851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3312
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