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Integrin αvβ3 and fibronectin upregulate Slug in cancer cells to promote clot invasion and metastasis

The blood clotting cascade is selectively involved in lung metastasis, but the reason for this selectivity is unclear. Here we show that tumor cells that metastasize predominantly to the lung, such as renal cell carcinoma (RCC) and soft tissue sarcoma (STS), have an inherent capacity to generate ext...

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Main Authors: Knowles, Lynn M., Gurski, Lisa A., Engel, Charlotte, Gnarra, James R., Maranchie, Jodi K., Pilch, Jan
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837455/
https://ncbi.nlm.nih.gov/pubmed/23966293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0602
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