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Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds

Screening of a phage library for peptides that bind to clotted plasma in the presence of liquid plasma yielded two cyclic decapeptides, CGLIIQKNEC (CLT1) and CNAGESSKNC (CLT2). When injected intravenously into mice bearing various types of tumors, fluorescein-conjugated CLT peptides accumulated in a...

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Bibliographische Detailangaben
Hauptverfasser: Pilch, Jan, Brown, Darren M., Komatsu, Masanobu, Järvinen, Tero A. H., Yang, Meng, Peters, David, Hoffman, Robert M., Ruoslahti, Erkki
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413849/
https://ncbi.nlm.nih.gov/pubmed/16476999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511219103
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