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Activated Src abrogates the Myc requirement for the G(0)/G(1) transition but not for the G(1)/S transition

The transcription factor Myc plays a central role in the control of cellular proliferation. Myc expression is induced by growth factors in a pathway mediated by cellular Src (c-Src), but it is not clear whether Myc induction or activity is required for malignant transformation by activated Src. We i...

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Main Authors: Prathapam, Tulsiram, Tegen, Sarah, Oskarsson, Thordur, Trumpp, Andreas, Martin, G. Steven
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413844/
https://ncbi.nlm.nih.gov/pubmed/16477001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511186103
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