Max deletion destabilizes MYC protein and abrogates Eµ-Myc lymphomagenesis

Although MAX is regarded as an obligate dimerization partner for MYC, its function in normal development and neoplasia is poorly defined. We show that B-cell-specific deletion of Max has a modest effect on B-cell development but completely abrogates Eµ-Myc-driven lymphomagenesis. While Max loss affe...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Mathsyaraja, Haritha, Freie, Brian, Cheng, Pei-Feng, Babaeva, Ekaterina, Catchpole, Jonathen T., Janssens, Derek, Henikoff, Steven, Eisenman, Robert N.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719623/
https://ncbi.nlm.nih.gov/pubmed/31395740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.325878.119
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