WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway

SLC12A cation/Cl(−) cotransporters are mutated in human disease, are targets of diuretics, and are collectively involved in the regulation of cell volume, neuronal excitability, and blood pressure. This gene family has two major branches with different physiological functions and inverse regulation:...

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Autors principals: de los Heros, Paola, Kahle, Kristopher T., Rinehart, Jesse, Bobadilla, Norma A., Vázquez, Norma, San Cristobal, Pedro, Mount, David B., Lifton, Richard P., Hebert, Steven C., Gamba, Gerardo
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413675/
https://ncbi.nlm.nih.gov/pubmed/16446421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510947103
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