WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters

NKCC1 and KCC2, related cation-chloride cotransporters (CCC), regulate cell volume and γ-aminobutyric acid (GABA)-ergic neurotranmission by modulating the intracellular concentration of chloride [Cl(−)]. These CCCs are oppositely regulated by serine-threonine phosphorylation, which activates NKCC1 b...

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Detalhes bibliográficos
Main Authors: Rinehart, Jesse, Vázquez, Norma, Kahle, Kristopher T., Hodson, Caleb A., Ring, Aaron M., Gulcicek, Erol E., Louvi, Angeliki, Bobadilla, Norma A., Gamba, Gerardo, Lifton, Richard P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191056/
https://ncbi.nlm.nih.gov/pubmed/21733846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.222893
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