Potentiation of Protein Kinase C ζ Activity by 15-Deoxy-Δ(12,14)-Prostaglandin J(2) Induces an Imbalance between Mitogen-Activated Protein Kinases and NF-κB That Promotes Apoptosis in Macrophages

Activation of the macrophage cell line RAW 264.7 with lipopolysaccharide (LPS) transiently activates protein kinase C ζ (PKCζ) and Jun N-terminal kinase (JNK) through a phosphoinositide-3-kinase (PI3-kinase)-dependent pathway. Incubation of LPS-treated cells with the cyclopentenone 15-deoxy-Δ(12,14)...

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Bibliographische Detailangaben
Hauptverfasser: Castrillo, Antonio, Través, Paqui G., Martín-Sanz, Paloma, Parkinson, Scott, Parker, Peter J., Boscá, Lisardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC141130/
https://ncbi.nlm.nih.gov/pubmed/12556480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.4.1196-1208.2003
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