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Potentiation of Protein Kinase C ζ Activity by 15-Deoxy-Δ(12,14)-Prostaglandin J(2) Induces an Imbalance between Mitogen-Activated Protein Kinases and NF-κB That Promotes Apoptosis in Macrophages
Activation of the macrophage cell line RAW 264.7 with lipopolysaccharide (LPS) transiently activates protein kinase C ζ (PKCζ) and Jun N-terminal kinase (JNK) through a phosphoinositide-3-kinase (PI3-kinase)-dependent pathway. Incubation of LPS-treated cells with the cyclopentenone 15-deoxy-Δ(12,14)...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC141130/ https://ncbi.nlm.nih.gov/pubmed/12556480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.4.1196-1208.2003 |
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