HIF-2α regulates Oct-4: effects of hypoxiaon stem cell function, embryonic development, and tumor growth

The division, differentiation, and function of stem cells and multipotent progenitors are influenced by complex signals in the microenvironment, including oxygen availability. Using a genetic “knock-in” strategy, we demonstrate that targeted replacement of the oxygen-regulated transcription factor H...

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Autors principals: Covello, Kelly L., Kehler, James, Yu, Hongwei, Gordan, John D., Arsham, Andrew M., Hu, Cheng-Jun, Labosky, Patricia A., Simon, M. Celeste, Keith, Brian
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2006
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1410808/
https://ncbi.nlm.nih.gov/pubmed/16510872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1399906
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