Rational design of low-molecular weight heparins with improved in vivo activity

Heparin and low-molecular weight heparins (LMWHs), complex, sulfated polysaccharides isolated from endogenous sources, are potent modulators of hemostasis. Heparin and LMWHs interact with multiple components of the coagulation cascade to inhibit the clotting process. Pharmaceutical preparations of t...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Sundaram, Mallik, Qi, Yiwei, Shriver, Zachary, Liu, Dongfang, Zhao, Ganlin, Venkataraman, Ganesh, Langer, Robert, Sasisekharan, Ram
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2003
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC141051/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12525684/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252643299
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