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Rational design of low-molecular weight heparins with improved in vivo activity

Heparin and low-molecular weight heparins (LMWHs), complex, sulfated polysaccharides isolated from endogenous sources, are potent modulators of hemostasis. Heparin and LMWHs interact with multiple components of the coagulation cascade to inhibit the clotting process. Pharmaceutical preparations of t...

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Bibliografske podrobnosti
Main Authors: Sundaram, Mallik, Qi, Yiwei, Shriver, Zachary, Liu, Dongfang, Zhao, Ganlin, Venkataraman, Ganesh, Langer, Robert, Sasisekharan, Ram
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC141051/
https://ncbi.nlm.nih.gov/pubmed/12525684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252643299
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