Notch3 and pre-TCR interaction unveils distinct NF-κB pathways in T-cell development and leukemia

Notch signaling plays a critical role in T-cell differentiation and leukemogenesis. We previously demonstrated that, while pre-TCR is required for thymocytes proliferation and leukemogenesis, it is dispensable for thymocyte differentiation in Notch3-transgenic mice. Notch3-transgenic premalignant th...

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Detalhes bibliográficos
Main Authors: Vacca, Alessandra, Felli, Maria Pia, Palermo, Rocco, Di Mario, Giuseppina, Calce, Angelica, Di Giovine, Monica, Frati, Luigi, Gulino, Alberto, Screpanti, Isabella
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409728/
https://ncbi.nlm.nih.gov/pubmed/16498412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600996
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