A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory

DNA demethylation plays a critical role in transcriptional regulation in differentiated somatic cells. However, there is no experimental evidence that CpG methylation in a small region of a genome restricts gene expression. Here, we show that the anti-CD3ɛ/CD28 antibody stimulation of human CD4(+) T...

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Detalhes bibliográficos
Main Authors: Murayama, Akiko, Sakura, Kazuhisa, Nakama, Mina, Yasuzawa-Tanaka, Kayoko, Fujita, Etsuko, Tateishi, Yukiyo, Wang, Yinan, Ushijima, Toshikazu, Baba, Tadashi, Shibuya, Kazuko, Shibuya, Akira, Kawabe, Yoh-ichi, Yanagisawa, Junn
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409718/
https://ncbi.nlm.nih.gov/pubmed/16498406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601012
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