Загрузка...
ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis
The GTPases Rab3a and Rab27a and their effectors Granuphilin/Slp4 and Noc2 are essential regulators of neuroendocrine secretion. Chronic exposure of pancreatic β-cells to supraphysiological glucose levels decreased selectively the expression of these proteins. This glucotoxic effect was mimicked by...
Сохранить в:
| Главные авторы: | , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1409716/ https://ncbi.nlm.nih.gov/pubmed/16498408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601008 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|