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ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis
The GTPases Rab3a and Rab27a and their effectors Granuphilin/Slp4 and Noc2 are essential regulators of neuroendocrine secretion. Chronic exposure of pancreatic β-cells to supraphysiological glucose levels decreased selectively the expression of these proteins. This glucotoxic effect was mimicked by...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1409716/ https://ncbi.nlm.nih.gov/pubmed/16498408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601008 |
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