Structural basis and prediction of substrate specificity in protein serine/threonine kinases
The large number of protein kinases makes it impractical to determine their specificities and substrates experimentally. Using the available crystal structures, molecular modeling, and sequence analyses of kinases and substrates, we developed a set of rules governing the binding of a heptapeptide su...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140887/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502784/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0134224100 |
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