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Structural basis for recruitment of glycogen synthase kinase 3β to the axin–APC scaffold complex
Glycogen synthase kinase 3β (GSK3β) is a serine/threonine kinase involved in insulin, growth factor and Wnt signalling. In Wnt signalling, GSK3β is recruited to a multiprotein complex via interaction with axin, where it hyperphosphorylates β-catenin, marking it for ubiquitylation and destruction. We...
Tallennettuna:
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2003
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140752/ https://ncbi.nlm.nih.gov/pubmed/12554650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg068 |
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