Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt signaling pathway, which promote the phosphorylation and degradation of β-catenin. While Axin is expressed ubiquitously, Axin2 mRNA was seen in a restricted pattern during mouse embryogenesis and organogenesis. Because man...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Jho, Eek-hoon, Zhang, Tong, Domon, Claire, Joo, Choun-Ki, Freund, Jean-Noel, Costantini, Frank
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2002
Témata:	Cell Growth and Development
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134648/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11809808/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.4.1172-1183.2002
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