Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt signaling pathway, which promote the phosphorylation and degradation of β-catenin. While Axin is expressed ubiquitously, Axin2 mRNA was seen in a restricted pattern during mouse embryogenesis and organogenesis. Because man...

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Detalhes bibliográficos
Main Authors: Jho, Eek-hoon, Zhang, Tong, Domon, Claire, Joo, Choun-Ki, Freund, Jean-Noel, Costantini, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134648/
https://ncbi.nlm.nih.gov/pubmed/11809808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.4.1172-1183.2002
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