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Structural basis for recruitment of glycogen synthase kinase 3β to the axin–APC scaffold complex

Glycogen synthase kinase 3β (GSK3β) is a serine/threonine kinase involved in insulin, growth factor and Wnt signalling. In Wnt signalling, GSK3β is recruited to a multiprotein complex via interaction with axin, where it hyperphosphorylates β-catenin, marking it for ubiquitylation and destruction. We...

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Udgivet i:EMBO J
Principais autores: Dajani, Rana, Fraser, Elizabeth, Roe, S.Mark, Yeo, Maggie, Good, Valerie M., Thompson, Vivienne, Dale, Trevor C., Pearl, Laurence H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2003
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140752/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12554650/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg068
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