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Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines
Insig-1 and Insig-2 are closely related proteins of the endoplasmic reticulum that play crucial roles in cholesterol homeostasis by inhibiting excessive cholesterol synthesis and uptake. In sterol-depleted cells Insig-1 is degraded at least 15 times more rapidly than Insig-2, owing to ubiquitination...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1405624/ https://ncbi.nlm.nih.gov/pubmed/16549805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600422103 |
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